Humans have been running simulations. A lot of simulations.
Millions upon millions, from a young age to past the middle age, spends hours solving puzzles, figuring out strategies, learning different ways of approaching a problem, understanding and working with given mechanics and parameters. They do this for hours a week. Some even every day. As we all know folks, the more you practice something, the better you get at it.
Some day the average gamer will resolve all of humanities problems in the most efficient way possible. I mean, have you seen the lengths to which some minmaxers will go?